• The Complete (but Practical) Guide to Phenytoin Dosing — tl;dr pharmacy

    Phenytoin Calculator This initial program provides some general dosage guidelines based on population averages for the Michaelis-Menten parameters (Km and Vmax). The recommendations do not take into the (1) existence of drugs (3) inter-patient variability (3) disease states which may significantly. Corrected Dilantin = (Measured Dilantin Level)/ ((Adjustment * Albumin) +). Adjustment = in patients with normal kidney function. In patients with creatinine clearance less than 20, adjustment is Nov 10,  · Corrected Total Phenytoin Level In patients with hypoalbuminemia, a corrected equation must be used to for reduced phenytoin protein This calculator uses the revised versions of the Winter-Tozer correction equation for patients with normal renal function and those with end-stage renal disease. Calculates a corrected calcium level for patients with hypoalbuminemia. MELD Score (Model For End-Stage Liver Disease) (12 and older) Stratifies severity of end-stage liver disease, for transplant HAS-BLED Score for Major Risk. Adjust phenytoin based on values. If consistently out of range, consider other antiepileptics. Concomitant use of valproic acid and some other drugs displaces phenytoin from plasma proteins and can lead to erratic levels. Whenever possible, a free phenytoin level should be utilized over a corrected . The program also calculates an “adjusted dose” for reported levels when the serum albumin level is. In general, the population kinetics estimate for phenytoin in adults is a Vd of L/kg. So, an average 75 kg person, the Vd of the drug by calculation is to be 52 L. The average total body fluid in a person is juuuust abouuut 45 L. So the drug HAS to be somewhere! Phenytoin sodium 'top-up' dose (mg) = (20 - measured concentration (mg/L)) x x wt (kg) Table 2 gives the approximate increase in concentration doses of –mg. For example, if the patient weighs 70kg and has a measured concentration of 5mg/L, a dose of mg will increase the concentration to around 20mg/L (5mg/L + 15mg/L). Corrected Phenytoin = Total Phenytoin Level / (( x albumin) + ) If clcr Corrected Phenytoin = Total Phenytoin Level / (( x albumin) + ).

    Simplifies assessment of head trauma patients compared to the GCS. Measures the impact fatigue takes on a patient's daily life. Predicts risk of hyperbilirubinemia in neonates. Hello Pharmacy Phriends! Next steps? Wells' Criteria for Pulmonary Embolism. Only use intravenous administration when these options are not feasible and where cardiac monitoring is available. The average total body fluid in a person is juuuust abouuut 45 L. Apfel Score for Postoperative Nausea and Vomiting. Assesses pain in patients with dementia.

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